Our skin plays an essential role as a physiological barrier. Human skin color is mainly determined by pigment melanin, which is secreted by dermal melanocytes through a melanin synthesis process call melanogenesis. Although melanin has a photoprotective and anti-free radical role, its accumulation in different parts of the skin, results in skin pigmentary disorders, such as brown or dark pigmentary spots which might become an esthetic problem.
The great improvement on knowledge about the melanogenesis allows the discovery of new and safe melanogenic inhibitors.
There is great interest in discovering depigmentation agents to prevent or treat hyperpigmentation disorders for medical or cosmetic reasons.
Today biotechnology is bringing new ingredients with important active properties for cosmetic formulations.
Currently, topical anti-melanogenic treatments have restricted uses because of side-effects or low stability. Therefore, we believe that a good depigmenting agents should be able to decrease melanogenesis as well as to be safe and stable.